Search results for "Pharmacological research"
showing 9 items of 9 documents
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-ind…
2018
Recent studies devoted to neuroprotection have focused on the role of the gamma-aminobutyric acid (GABA) system in regulating neuroinflammatory processes which play a key role in the neurodegenerative processes observed in Alzheimer's disease (AD) by inducing glial cell overactivation and impairing neurotransmission. Data on the efficacy of classical GABA-A and GABA-B receptor agonists (muscimol and baclofen, respectively) in animal models of AD are not available. Moreover, no published studies have examined the ability of optimal doses of these compounds to prevent neuroinflammation, the alterations in neurotransmission and cognitive deficits. In the present study, we used a non-transgenic…
Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase E…
2018
Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting millions of people worldwide. At present, there is no effective cure for PD; treatments are symptomatic and do not halt progression of neurodegeneration. Extracellular vesicles (EVs) can cross the blood–brain barrier and represent promising alternative to the classical treatment strategies. In the present study, we examined therapeutic effects of intranasal administration of EVs derived from human exfoliated deciduous teeth stem cells (SHEDs) on unilateral 6-hydroxydopamine (6-OHDA) medial forebrain bundle (MFB) rat model of PD. CatWalk gait tests revealed that EVs effectively suppressed 6-OHDA-…
Perspectives of Pharmacology over the Past 100 Years
2019
It is fitting that the 100th anniversary of the Handbook of Experimental Pharmacology celebrates not only its founding but also the founding of experimental pharmacology as both had their beginnings in Germany. Founded in 1919 by Arthur Heffter (1859–1925) as the “Handbuch der Experimentellen Pharmakologie” and renamed to its current title in 1937, the Handbook has continued to capture the emergence and developments of experimental pharmacology since the initial systematic work of Rudolf Buchheim and his student Oswald Schmiedeberg. Heffter, the first Chairman of the German Society of Pharmacology, was also responsible for isolating mescaline as the active psychedelic component from the pey…
О галеновыхъ препаратахъ изъ торговыхъ сортовъ валерiаны
1908
Latviešu farmaceita, Latvijas Universitātes Medicīnas fakultātes pirmā dekāna (1919-1920), profesora (1919), farmācijas goda doktora (1929) Eduarda Otto Zariņa disertācija farmācijas maģistra grāda aizstāvēšanai par galēniskiem preparātiem, kas pagatavoti no dažādu šķirņu baldriānu saknēm. 1923. gadā E. Zariņa mag. pharm. grādu pielīdzināja LU doktora grādam.
Farmakognozija, 1. Vispārīgā daļa
1940
Influence of Pharmacokinetic Variations on the Pharmacological Properties of Adriamycin
1972
Whenever it appears impossible to modify the chemical structure of drugs with a high and established therapeutic activity but a low chemotherapeutic index, pharmacological research has to find other ways of improving the chemotherapeutic index. This problem is particularly important in the case of antitumor drugs, thus justifying research into the most suitable choice of dosage and routes of administration, as well as into the pharmacological associations which enable tumor cells to be hit at various stages of the reproductive cycle. Alternatively, the therapeutic index could be improved by the use of antagonistic compounds (like, for example, methotrexate and folinic acid) which act upon t…
Melanocortins: regulators of behavioural and neurochemical processes
2004
Farmakoloģija ar toksikoloģiju un receptūru: mācību grāmata studentiem un ārstiem
1942
Grāmatas nodaļas: Autora priekšvārdi. Saīsinājumi I. Vispārīgā farmakoloģija II. Zāļu parakstīšanas mācība III. Nemetālu un metālu savienojumi IV. Alifātiskās rindas organiskās substances V. Aromātiskās rindas organiskās substances VI. Alkaloīdl VII. Glikozīdi VIII. Rūgtvielas IX. Ēteriskās eļļas X. Vitamīni XI. Hormoni XII. Hormonoīdi jeb II šķiras hormoni XIII. Fermenti XIV. Baktēriju produkti un specifiskie serumi XV. Līdzekļi nespecifiskai kairināšanas, proteīna jeb imūnterapijai XVI. Pirmā palīdzība akūtas saindēšanās gadījumos XVII. Indikācijas. Personu saraksts. Reģistrs
Sammlung offizineller Pflanzen
1828
Izdevums bez titullapas, autors-ilustrators A. Henry uzrādīts tikai uz grāmatas iesējuma muguriņas. Augu nosaukumi pie attēliem doti tikai latīņu valodā.